Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation
نویسندگان
چکیده
منابع مشابه
Calcium signaling in human airway goblet cells following purinergic activation.
Despite the general importance of Ca(2+) signaling in signal transduction, and of goblet cell mucin hypersecretion in inflammatory pulmonary diseases, measurement of airway goblet cell intracellular Ca(2+) (Ca(i)(2+)) has not been reported. In this article, we describe the results of experiments measuring Ca(i)(2+) in primary cultures of human bronchial goblet cells after stimulation with the p...
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The NLRP3 inflammasome is a protein complex involved in IL-1β and IL-18 processing that senses pathogen- and danger-associated molecular patterns (PAMPs and DAMPs). One step- or two step-models have been proposed to explain the tight regulation of IL-1β production during inflammation. Moreover, cellular stimulation triggers adenosine triphosphate (ATP) release and subsequent activation of purin...
متن کاملPurinergic Regulation of Neutrophil Function
Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through activation of P2 receptors, whereas adenosine mostly functions as an anti-inflammatory molecule through activation of P1 receptors. Neutrophils ar...
متن کاملPurinergic Signaling in Bone
1 Research Center for Ageing and Osteoporosis, Departments of Diagnostics and Medicine, Copenhagen University Hospital Glostrup, 2600 Glostrup, Denmark 2Department of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, 44121 Ferrara, Italy 3 Bone Biology Laboratory, Department of Cell and Developmental Biology, University College London, London WC...
متن کاملExtracellular purinergic signaling in pancreas.
recognized as important extracellular signaling molecules in many biological systems (1). In epithelia, ATP signaling is thought to regulate fluid transport, and exocrine glands are one of the first epithelia where the effect of ATP on ion channels and Ca signaling was observed (2, 3). Nevertheless, many steps in ATP signaling, also known as purinergic signaling, remain to be clarified. This in...
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ژورنال
عنوان ژورنال: Science Signaling
سال: 2010
ISSN: 1937-9145
DOI: 10.1126/scisignal.2000549